What Is Proteolytic Cleavage and Why Does It Matter? Kumar Jeetendra | February 24, 2025 In cellular processes, ‘proteolytic cleavage’ is a crucial biomolecular reaction, which can be the breakdown of a protein into its constituent parts termed as amino acids. This occurs through a series of complex reactions which may involve several biomolecules ranging from prosthetic activators to complex neuropeptides. Broadly speaking, it is the breakdown of larger proteins …